In the liver, it is non-specifically metabolized by CYP1A2, CYP3A4, and CYP2C9 via 2-hydroxylation into 2-hydroxyestradiol, and by CYP2C9, CYP2C19, and CYP2C8 via 17β-hydroxy dehydrogenation into estrone, 9] with various other cytochrome P450 (CYP) enzymes and metabolic transformations also being involved. Must not exceed the maximum recommended dose. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling . This category implies possible clinical applicability in body site where the drug is physiologically concentrated. Simvastatin was initially marketed by Merck & Co under the trade name Zocor, but is available generically in most countries following the patent expiry. The serum concentration of Colchicine can be increased when it is combined with Sumatriptan. |