I was told to get off of it, which I did. If coadministration is necessary, use caution and monitor for increased paclitaxel side effects, including myelosuppression and peripheral neuropathy. While blood studies may detect early peripheral blood changes, such as leukopenia, reticulocytopenia, or granulocytopenia, before they become irreversible, such studies cannot be relied on to detect bone marrow depression prior to development of aplastic anemia. Other medicines not listed above may also interact with roxithromycin. Cefpodoxime may also be used for purposes not listed in this medication guide. However, the lower concentration of unchanged drug in extensive metabolizers is balanced by the formation of active hydroxyl metabolites, yielding insignificant clinical differences in therapeutic endpoints. |